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1

Expanding Insight into Asymmetric Palladium-Catalyzed Allylic Alkylation of N-Heterocyclic Molecules and Cyclic Ketones

Bennett, Nathan B., Duquette, Douglas C., Kim, Jimin, Liu, Wen-Bo, Marziale, Alexander N., Behenna, Douglas C., Virgil, Scott C., Stoltz, Brian M.

Journal:

Chemistry - A European Journal

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

2

Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Planken, Simon, Behenna, Douglas C., Nair, Sajiv K., Johnson, Theodore O., Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.86 MB

english, 2017

3

Deracemization of Quaternary Stereocenters by Pd-Catalyzed Enantioconvergent Decarboxylative Allylation of Racemic β-Ketoesters

Justin T. Mohr, Douglas C. Behenna, Andrew M. Harned, Brian M. Stoltz

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 133 KB

english, 2005

4

Synthesis of the Carbocyclic Core of Zoanthenol: Implementation of an Unusual Acid-Catalyzed Cyclization

Douglas C. Behenna, Jennifer L. Stockdill, Brian M. Stoltz

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 316 KB

english, 2007

5

Biologie und Chemie der Zoanthamin-Alkaloide

Douglas C. Behenna, Jennifer L. Stockdill, Brian M. Stoltz

Journal:

Angewandte Chemie

Year:

2008

Language:

german

File:

PDF, 1.50 MB

german, 2008

6

Unusual Allylpalladium Carboxylate Complexes: Identification of the Resting State of Catalytic Enantioselective Decarboxylative Allylic Alkylation Reactions of Ketones

Nathaniel H. Sherden, Douglas C. Behenna, Scott C. Virgil, Brian M. Stoltz

Journal:

Angewandte Chemie

Year:

2009

Language:

english

File:

PDF, 497 KB

english, 2009

7

Deracemization of Quaternary Stereocenters by Pd-Catalyzed Enantioconvergent Decarboxylative Allylation of Racemic β-Ketoesters

Justin T. Mohr, Douglas C. Behenna, Andrew M. Harned, Brian M. Stoltz

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 133 KB

english, 2005

8

Synthesis of the Carbocyclic Core of Zoanthenol: Implementation of an Unusual Acid-Catalyzed Cyclization

Douglas C. Behenna, Jennifer L. Stockdill, Brian M. Stoltz

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 316 KB

english, 2007

9

The Biology and Chemistry of the Zoanthamine Alkaloids

Douglas C. Behenna, Jennifer L. Stockdill, Brian M. Stoltz

Journal:

Angewandte Chemie International Edition

Year:

2008

Language:

english

File:

PDF, 1.49 MB

english, 2008

10

Unusual Allylpalladium Carboxylate Complexes: Identification of the Resting State of Catalytic Enantioselective Decarboxylative Allylic Alkylation Reactions of Ketones

Nathaniel H. Sherden, Douglas C. Behenna, Scott C. Virgil, Brian M. Stoltz

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 497 KB

english, 2009

11

Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope, and Mechanistic Studies

Dr. Douglas C. Behenna, Dr. Justin T. Mohr, Dr. Nathaniel H. Sherden, Smaranda C. Marinescu, Prof. Andrew M. Harned, Dr. Kousuke Tani, Dr. Masaki Seto, Dr. Sandy Ma, Dr. Zoltán Novák, Dr. Michael R. K

Journal:

Chemistry - A European Journal

Year:

2011

Language:

english

File:

PDF, 1.40 MB

english, 2011

12

The Enantioselective Tsuji Allylation.

Douglas C. Behenna, Brian M. Stoltz

Journal:

Year:

2005

File:

PDF, 40 KB

2005

13

An efficient synthesis of the carbocyclic core of zoanthenol

Jennifer L. Stockdill, Douglas C. Behenna, Andrew McClory, Brian M. Stoltz

Journal:

Year:

2009

Language:

english

File:

PDF, 308 KB

english, 2009

14

Unexpected decarbonylation during an acid-mediated cyclization to access the carbocyclic core of zoanthenol

Jennifer L. Stockdill, Douglas C. Behenna, Brian M. Stoltz

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 569 KB

english, 2009

15

Confirmation of the absolute configuration of (−)-aurantioclavine

Douglas C. Behenna, Shyam Krishnan, Brian M. Stoltz

Journal:

Tetrahedron Letters

Year:

2011

Language:

english

File:

PDF, 490 KB

english, 2011

16

Synthesis of P1-Citronellyl-P2-α-d-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG

Predrag Cudic, Douglas C. Behenna, Michael K. Yu, Ryan G. Kruger, Lawrence M. Szewczuk, Dewey G. McCafferty

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 147 KB

english, 2001

17

Synergy and duality in peptide antibiotic mechanisms

Dewey G McCafferty, Predrag Cudic, Michael K Yu, Douglas C Behenna, Ryan Kruger

Journal:

Current Opinion in Chemical Biology

Year:

1999

Language:

english

File:

PDF, 292 KB

english, 1999

18

Functional Analysis of the Lipoglycodepsipeptide Antibiotic Ramoplanin

Predrag Cudic, Douglas C Behenna, James K Kranz, Ryan G Kruger, A.Joshua Wand, Yuri I Veklich, John W Weisel, Dewey G McCafferty

Journal:

Chemistry & Biology

Year:

2002

Language:

english

File:

PDF, 365 KB

english, 2002

19

Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams

Behenna, Douglas C., Liu, Yiyang, Yurino, Taiga, Kim, Jimin, White, David E., Virgil, Scott C., Stoltz, Brian M.

Journal:

Nature Chemistry

Year:

2011

Language:

english

File:

PDF, 328 KB

english, 2011

20

The Reaction Mechanism of the Enantioselective Tsuji Allylation: Inner-Sphere and Outer-Sphere Pathways, Internal Rearrangements, and Asymmetric C–C Bond Formation

Keith, John A., Behenna, Douglas C., Sherden, Nathaniel, Mohr, Justin T., Ma, Sandy, Marinescu, Smaranda C., Nielsen, Robert J., Oxgaard, Jonas, Stoltz, Brian M., Goddard, William A.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 1.66 MB

english, 2012

21

Development of (Trimethylsilyl)ethyl Ester Protected Enolates and Applications in Palladium-Catalyzed Enantioselective Allylic Alkylation: Intermolecular Cross-Coupling of Functionalized Electrophiles

Reeves, Corey M., Behenna, Douglas C., Stoltz, Brian M.

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 584 KB

english, 2014

22

A Facile and Modular Synthesis of Phosphinooxazoline Ligands

Tani, Kousuke, Behenna, Douglas C., McFadden, Ryan M., Stoltz, Brian M.

Journal:

Organic Letters

Year:

2007

Language:

english

File:

PDF, 58 KB

english, 2007

23

The Enantioselective Tsuji Allylation

Behenna, Douglas C., Stoltz, Brian M.

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 68 KB

english, 2004

24

The Inner-Sphere Process in the Enantioselective Tsuji Allylation Reaction with ( S )- t -Bu-phosphinooxazoline Ligands

Keith, John A., Behenna, Douglas C., Mohr, Justin T., Ma, Sandy, Marinescu, Smaranda C., Oxgaard, Jonas, Stoltz, Brian M., Goddard, William A.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 101 KB

english, 2007

25

Catalytic Enantioselective Decarboxylative Protonation

Mohr, Justin T., Nishimata, Toyoki, Behenna, Douglas C., Stoltz, Brian M.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 56 KB

english, 2006

26

Simple Enantioselective Approach to Synthetic Limonoids

Behenna, Douglas C., Corey, E. J.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 103 KB

english, 2008

27

Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

Korch, Katerina M., Eidamshaus, Christian, Behenna, Douglas C., Nam, Sangkil, Horne, David, Stoltz, Brian M.

Journal:

Angewandte Chemie International Edition

Year:

2015

Language:

english

File:

PDF, 777 KB

english, 2015

28

Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

Korch, Katerina M., Eidamshaus, Christian, Behenna, Douglas C., Nam, Sangkil, Horne, David, Stoltz, Brian M.

Journal:

Angewandte Chemie

Year:

2015

Language:

english

File:

PDF, 766 KB

english, 2015

29

Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Cyclopentanones

Craig, Robert A., Loskot, Steven A., Mohr, Justin T., Behenna, Douglas C., Harned, Andrew M., Stoltz, Brian M.

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 570 KB

english, 2015

30

Discovery of 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988), A Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W., Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Douglas Carl, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P., Feng, Jun Li,

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 4.17 MB

english, 2016

31

ChemInform Abstract: Natural Products as Inspiration for Reaction Development. Catalytic Enantioselective Decarboxylative Reactions of Prochiral Enolate Equivalents

Behenna, Douglas C., Stoltz, Brian M.

Journal:

Year:

2014

File:

PDF, 18 KB

2014

32

ChemInform Abstract: Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Cyclopentanones.

Craig, Robert A., Loskot, Steven A., Mohr, Justin T., Behenna, Douglas C., Harned, Andrew M., Stoltz, Brian M.

Journal:

Year:

2016

File:

PDF, 35 KB

2016

33

ChemInform Abstract: Expanding Insight into Asymmetric Palladium-Catalyzed Allylic Alkylation of N-Heterocyclic Molecules and Cyclic Ketones.

Bennett, Nathan B., Duquette, Douglas C., Kim, Jimin, Liu, Wen-Bo, Marziale, Alexander N., Behenna, Douglas C., Virgil, Scott C., Stoltz, Brian M.

Journal:

Year:

2013

File:

PDF, 48 KB

2013

34

ChemInform Abstract: Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation.

Korch, Katerina M., Eidamshaus, Christian, Behenna, Douglas C., Nam, Sangkil, Horne, David, Stoltz, Brian M.

Journal:

Year:

2015

File:

PDF, 32 KB

2015

35

Enantioselective Synthesis of Caprolactam and Enone Precursors to the Heterocyclic DEFG Ring System of Zoanthenol

Bagdanoff, Jeffrey T., Behenna, Douglas C., Stockdill, Jennifer L., Stoltz, Brian M.

Journal:

European Journal of Organic Chemistry

Year:

2016

Language:

english

File:

PDF, 864 KB

english, 2016

36

ChemInform Abstract: Development of (Trimethylsilyl)ethyl Ester Protected Enolates and Applications in Palladium-Catalyzed Enantioselective Allylic Alkylation: Intermolecular Cross-Coupling of Functionalized Electrophiles.

Reeves, Corey M., Behenna, Douglas C., Stoltz, Brian M.

Journal:

Year:

2014

File:

PDF, 26 KB

2014

37

Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors

Niessen, Sherry, Dix, Melissa M., Barbas, Sabrina, Potter, Zachary E., Lu, Shuyan, Brodsky, Oleg, Planken, Simon, Behenna, Douglas, Almaden, Chau, Gajiwala, Ketan S., Ryan, Kevin, Ferre, RoseAnn, Laze

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 2.75 MB

english, 2017

38

Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation

Liu, Yiyang, Liniger, Marc, McFadden, Ryan M, Roizen, Jenny L, Malette, Jacquie, Reeves, Corey M, Behenna, Douglas C, Seto, Masaki, Kim, Jimin, Mohr, Justin T, Virgil, Scott C, Stoltz, Brian M

Journal:

Beilstein Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 890 KB

english, 2014

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